Frank G. Ondrey, MD, PhD

Co-Leader, Carcinogenesis and Chemoprevention Program
Frank Ondrey

United States

Contact Dr. Ondrey:
Dr. Frank Ondrey MD PhD is a Professor of Otolaryngology in the Department of Otolaryngology. Dr. Ondrey practices head and neck cancer surgery/otolaryngology for M Health at the University of Minnesota and in St. Paul. He received his MD and PhD (Biochemistry) from Rush Medical college/Rush university before completing his surgical training at the University of Minnesota. He served as a Senior Staff Surgeon at the National Institutes of Health before joining the faculty of the University of Minnesota. He is an expert in the multidisciplinary management of Head and neck cancer of the oral cavity, larynx, and related structures. His research is primarily focused on early cancers of the head and neck and their prevention and he has been a principal investigator on the majority of government sponsored oral cancer prevention trials over 20 years . He has served for many years on various review panels of the National Cancer Institute in Washington DC. He is co-leader of the Carcinogenesis and Chemoprevention for the Masonic Cancer Center.


MD, Rush Medical College, 1989
PhD, Rush University, 1994
Surgical Residency, Hennepin County Medical Center 1989-1991
Otolaryngology Residency, University of Minnesota, 1991-1995
Fellowship Head and Neck Cancer Clinical Research Fellowship NIDCD/NIH, 1995-1998

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Research Summary/Interests

Dr. Ondrey principal interest is in head and neck cancer clinical prevention. For over 20 years he has conducted laboratory studies that he has brought to his patients in several cancer prevention clinical trials that have been federally supported. He examines cell maturation pathways and inflammation that can be targeted by FDA approved drugs that can be safely taken by patients to prevent high risk conditions from resulting in cancer.

Clinical Information

Dr. Ondrey is certified by the American Board of Otolaryngology and sees patients for M Health at the Clinics and Surgery Center on Fulton street in Minneapolis on the University of Minnesota campus. He also sees patients in the HealthPartners system at his office on Phalen BLVD. in St Paul.


Where Dr. Ondrey Sees Patients:

  • Minneapolis M Health
  • Health Partners, St. Paul