Genetic Mechanisms Program

The Masonic Cancer Center's Genetic Mechanisms (GM) research program consists of 34 faculty members at all ranks from 10 different departments within the Medical School on the Minneapolis and Duluth campuses, the School of Dentistry, the College of Science and Engineering, the College of Pharmacy, and the School of Veterinary Medicine.

The scientific goals of the program are to define and understand the genetic changes that occur during cancer development, including the specific changes that drive tumor initiation and progression and those that influence cancer susceptibility.

See Genetic Mechanisms Program Members

Research themes:

  • Cancer gene discovery and analysis: genetics of cancer susciptibility and single nucleotide polymorphism (SNP) analysis, genetic screens for cancer-relevant phenotypes in animal models, functional analysis of cancer genes, and genome-wide analysis of gene expression
  • Genome stability: chromosome segregation; DNA replication, repair and recombination; DNA
  • Cancer gene therapy and genome modification: building animal and human cell-based cancer models, gene therapy

Program Leaders

Stephanie Huang

Stephanie Huang, PhD
Professor, Department of Experimental and Clinical Pharmacology (ECP)




Masato Yamamoto

Masato Yamamoto, MD, PhD
Eugene C. and Gail V. Sit Chair in Pancreatic and Gastrointestinal Cancer Research, Vice-Chair of Surgical Science