Cellular Mechanisms Program
Members of this program seek to define and understand the spectrum of altered signaling pathways and their components that contribute to cancer initiation, promotion, and disease progression. The goal is to facilitate the step-wide translation of this knowledge into novel strategies aimed at prevention, early detection, diagnostics and prognosis, and treatment of cancer.
Programmatic focus includes the actions of cell surface receptors or nuclear receptors (i.e., steroid hormone receptors) and their ligands (the first messengers), intracellular second messengers, protein kinase cascades, and other signaling molecules that serve as modifiers of signal strength and duration, and the endpoints (substrates) of cell signaling pathways that regulate gene expression (transcription factors and their co-regulators, including DNA modifying enzymes).
Signal Transduction within and between tumor cells
Epigenetic Regulation of the Cancer Transcriptome
Tumor Stroma Remodeling
The Cellular Mechanisms program holds monthly meetings in which single projects or multiple projects within related topic areas are discussed in an interactive roundtable format.
Carol Lange, PhD
Professor of Medicine, Division of Hematology, Oncology and Transplantation
Daniel Harki, PhD
Associate Professor and Director of Graduate Studies, Department of Medicinal Chemistry