Comparative Pathology
The Comparative Pathology Shared Resource (CPSR), led by Dr. Davis Seelig, provides pathology support and expertise to Masonic Cancer Center members and non-members who use laboratory animals in their research.
We are a full-service pathology laboratory that offers support from the initial stages of the experiment (study design and preparation of research grant) through to the final stages (assisting with manuscript preparation after the results have been analyzed). We offer technical support for tissue collection, processing, and preparation of histological sections, and we also offer pathology support for interpretation and imaging of the tissues.
Routine requests, including tissue processing, H&E and special staining, and slide scanning, can be completed within 3-5 days of sample receipt. Most projects requiring pathologist analysis are completed within 4-6 weeks of sample submission (pending project scale). Please contact us for specific quoting and turnaround time information.
We are an a la carte laboratory that strives to meet the unique needs of our clientele regardless of the size and scope of the project. Investigators may use our resource for all of their comparative pathology needs or may request selected components (e.g., preparation of histological sections from a previously prepared tissue block or staining previously prepared glass slides).
Services
- Necropsy support and tissue collection
- Paraffin embedding
- Tissue sectioning
- Staining (H&E and Special Stains)
- Immunohistochemistry (Single and Multi-Label)
- Antibody validation and IHC protocol development
- TMA creation
- Digital slide Scanning
- Frozen section preparation
- Slide preparation for spatialomics studies
- Pathologist analysis (narrative, semi-quantitative, and quantitative using the HALO image analysis platform)
- Project planning, grant support, and manuscript preparation
Areas of Research
- Cancer
- Immunology
- Infectious disease
- Metabolic diseases
- Genetic diseases
- Toxicology
- Medical devices
- Regulatory pathology
- Organoid pathology
Common Laboratory Species
- Mouse
- Rat
- Hamster
- Guinea pig
- Rabbit
- Pig
- Non-human primate
Our pathologists have comprehensive training across numerous species. If you work with a non-traditional laboratory animal, please contact us to discuss how we can assist you.