Gunda I. Georg, PhD
Professor Georg and her group have published over 250 scientific articles and are involved in the design, semisynthesis, total synthesis, and evaluation of biologically active agents. Current therapeutic areas include cancer, male and female non-hormonal contraception, cancer, and epilepsy.
These projects require the development of synthetic methods, synthesis of natural products, and structure-activity studies aimed at improving the therapeutic efficacy of lead compounds, including natural products, and hits from high throughput screening.
Interdisciplinary projects are a main focus in the Georg group, involving medicinal chemistry, biochemistry, screening, structure-based drug design, pharmacology, pharmaceutical chemistry and reproductive biology. Active collaboration exists between the Contraception Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, several research groups at the University of Minnesota, and around the country.
Professor Georg is the PI of a NICHD P50 “Contraceptive Discovery, Development and Behavioral Research Center” that involves six institutions. She is the co-inventor of LusedraTM, which was marketed by Eisa Pharmaceuticals, of Minnelide, an anticancer agent in phase II clinical trials, and of Gamendazole, a male contraceptive agent in preclinical development.
Awards & Recognition
Professor Georg is the co-Editor-in-Chief of the Journal of Medicinal Chemistry of the American Chemical Society.
She has served as a member of review panels for the National Institutes of Health, the National Science Foundation, the American Cancer Society and others.
In 2017 she was inducted into the Medicinal Chemistry Hall of Fame of the Division of Medicinal Chemistry of the American Chemical Society and named Research Exemplar by the Research Exemplar Project of Washington University in St. Louis.
She is a Fellow of the American Association for the Advancement of Science
and the American Chemical Society.
In 2013 she received the Ernest H. Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy, was named a Fellow of the American Chemical Society, and was the International Chair of Therapeutic Innovation, Paris, France (LERMIT).
She was the 2000 Sato Memorial International Award recipient of the Pharmaceutical Society of Japan, and the 2001 Nolan and Gloria Sommer Award Winner (University of Nebraska).
In 2020 she received the Alfred Burger Award in Medicinal Chemistry of the American Chemical Society.
Recent Named Lectures:
2019 G. Van Greene Distinguished Lecture, Mercer University, College of Pharmacy
2019 3M/Ronald A. Mitsch Lecture in Chemistry. Hamlin University, Saint Paul
2019 Matzuk Lecture, Baylor College of Medicine
2010 Henry A. Lardy Lecture, South Dakota State University Department of Chemistry
2010 Sosnovsky Distinguished Lectureship, University of Wisconsin-Milwaukee,
Department of Chemistry
2018 Sigma-Aldrich Lectureship, Northwestern University, Center for Innovation and Drug Discovery
2017 J. Doyle Smith / Larry Winter Lecture, Virginia Commonwealth University
2016 Varro E. Tyler Distinguished Lecture, Purdue University College of
Pharmacy and Department of Medicinal Chemistry and Molecular
2015 Karcher-Barton-Aldrich Award Lecture, The University of Oklahoma, Department of Chemistry and Biochemistry
2015 Nieuwland Lectureship, Department of Chemistry, Notre Dame University
Regents Professor and Department Head, Department of Medicinal Chemistry
Robert Vince Endowed Chair
McKnight Presidential Chair
Faculty, MS and PhD Programs in Pharmacology
PhD, Medicinal Chemistry, Philipps University Marburg, Germany, 1975
BS, Philipps Universitat Marburg, 1975
Postdoctoral, Philipps Universitat Marburg, 1981
Postdoctoral, University of Ottawa, 1982
Research Funding Grants
NICHD U54 HD093540, NICHD 1 R61 HD099743, 75N95019D00031, R01 HD012623
- WO2010129918 A8
- US20140323748 A1
- WO 2015/117024A1
- WO 2016/149540 A1
Faber, E. B.; Tian, D.; Burban, D.; Levinson, N. M.; Hawkinson, J. E.; Georg, G. I. Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid(ANS) in Cyclin-dependent Kinase 2. ACS Chem. Biol. 2020, 15, 1759-1764.
Holth, T. A. D.; Walters, M.; Hutt, O. E.; Georg, G. I. Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds. ACS Comb. Sci. 2020, 22, 150-155. DOI: 10.1021/acscombsci.9b00186.
Wang, N.; Faber, E. B.; Georg, G. I. Synthesis and Spectral Properties of 8-Anilinonaphthalene-1- Sulfonic Acid (ANS) Derivatives Prepared by Microwave-Assisted Copper(0)-Catalyzed UllmanReaction. ACS Omega 2019, 4, 18472-18477.
? Syeda, S. S.; Sánchez, G.; Hong, K. H.; Hawkinson, J.; Georg, G. I.; Blanco, G. Design, Synthesis, In Vitro and In Vivo Evaluation of Ouabain Analogs as Potent and Selective Na,K- ATPase a4 Isoform Inhibitors for Male Contraception.J. Med. Chem. 2018, 61, 1800-1820.
? Paulson,C. N.; Guan,X.; Ayoub,A. M.; Chan, A.; Karim, R. M.; Pomerantz,W. K. C.;Schönbrunn, E.; Georg,G. I.; Hawkinson, J. E.Design, Synthesis and Characterization of a Pan- BET Fluorescent Polarization Bromodomain Probe. ACS Med. Chem. Lett. 2018, 9, 1223-12229.