Andrew Venteicher, MD, PhD
Dr. Andrew Venteicher specializes in minimally invasive, endoscopic endonasal, and traditional open microsurgical approaches to cranial base tumors and cerebrovascular diseases. He is the neurosurgical director of the Center for Cranial Base Surgery, which focuses on diagnosis and comprehensive treatment for patients with tumors along the base of the brain, pituitary gland, and brainstem.
Dr. Venteicher earned his BA from the University of Pennsylvania in Mathematics, Biochemistry and Economics, as well as an MS in Chemistry. He attended Stanford for both his MD and PhD in Biophysics, trained at Harvard Medical School for his residency, and was selected for the prestigious cerebrovascular and cranial base fellowship at the University of Pittsburgh.
On the research side, Dr. Venteicher is part of a new translational research initiative between the U's Medical School and the Masonic Cancer Center that is exploring the genomics of brain tumors. His laboratory focuses on using new molecular techniques to understand how and why brain tumors develop and resist chemotherapy and radiation treatment. Translational research efforts such as these are of particular importance to identify new treatment options for patients with these diseases. He will one of the first to move into the new multidisciplinary consortium located at the Masonic Cancer Center Discovery Labs in the Malcolm Moos Health Sciences Tower on campus.
Awards & Recognition
- Ernest Brown Jr award, University of Pennsylvania
- Markris Memorial award, University of Pennsylvania
- Medical Scientist Training Program, Stanford University, 2003
- Teaching assistantship in Medical Immunology, Stanford University, 2003-2004
- Research fellowship, American Society of Hematology, 2007
- Outstanding presentation award, American Association of Cancer Research, 2008
- Scholarship award, Korean American Medical Association, 2010
- Teaching assistantship in Neuroanatomy, Harvard Medical School, 2014-2015
- Excellence in adult basic research award, Society of Neuro-Oncology, 2015
- Preuss award, American Association of Neurological Surgeons, 2016
- Emerging Leaders in Brain Cancer Research, 2018
Professional Associations
- American Association of Neurological Surgeons
- Congress of Neurological Surgeons
- North American Skull Base Society
- Society of Neuro-Oncology
Education
Assistant Professor and Neurosurgical Director of the Center for Skull Base and Pituitary Surgery, Department of Neurosurgery
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
Faculty, Graduate Program in Neuroscience
Cranial base neurosurgeon
MD, Stanford University
Residency in Neurosurgery, Harvard Medical School, Massachusetts General Hospital
Clinical fellowship in Cranial Base and Cerebrovascular Neurosurgery, University of Pittsburgh
PhD, Biophysics, Stanford University
MS, Chemistry, University of Pennsylvania
BA, Biochemistry, Economics, and Mathematics, University of Pennsylvania
Post-doctoral fellowship, Harvard Medical School, Massachusetts General Hospital
Research
Research Summary/Interests
On the research side, Dr. Venteicher is part of a new translational research initiative between the U's Medical School and the Masonic Cancer Center that is exploring the genomics of brain tumors. His laboratory focuses on using new molecular techniques to understand how and why brain tumors develop and resist chemotherapy and radiation treatment. Translational research efforts such as these are of particular importance to identify new treatment options for patients with these diseases. He will one of the first to move into the new multidisciplinary consortium located at the Masonic Cancer Center Discovery Labs in the Malcolm Moos Health Sciences Tower on campus.
Research Funding Grants
- American Brain Tumor Association Discovery award, 2015-2016
- National Institutes of Health R25 award, 2015-2016
- Neurosurgery Research and Education Foundation award, 2015-2016
- National Institutes of Health K12 award, 2019
- Burroughs Wellcome Foundation CAMS award, 2019
- Pittsburgh Foundation, Copeland award, 2019
Publications
Clinical Publications
- Goldschmidt E, Venteicher AS, Nunez M, Snyderman CH, Gardner PA. Endoscopic endonasal approach for brainstem cavernous malformation. Journal of Neurosurgery, 2019.
- Venteicher AS, Mukherjee D, Fernandez-Miranda JC, Wang EW, Snyderman CH, Gardner PA. Endoscopic endonasal approach for resection of a suprasellar meningioma. Congress of neurological Surgeons NEXUS Online Resource, www.cns.org/nexus, May 2019.
- Venteicher AS*, Quddusi A*, Coumans JV. Anterolateral approach for a cervical nerve root compression syndrome due to an ectatic vertebral artery. Operative Neurosurgery 2018 Dec 10; doi: 10.1093/ons/opy282. PMID 30535126. *Co-first author.
- Yang JC*, Venteicher AS*, Koch MJ, Stapleton CJ, Friedman GN, Venteicher EM, Shin JH. Myopericytoma at the craniocervical junction: Clinicopathological report and review of a rare perivascular neoplasm. Neurosurgery. 2018 Jun 8; doi: 10.1093/neuros/nyy262. PMID 29889275. *Co-first author.
- Venteicher AS*, Kumar JI*, Murphy EA, Gray ST, Holbrook EH, Curry WT. Phantosmia and dysgeusia following endoscopic transcribriform approaches to olfactory groove meningiomas. Journal of Neurological Surgery Part B: Skull Base 2017 Jun; 78(3): 245-250. *Co-first author.
- Sarmiento JM*, Venteicher AS*, Patil CG. Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas. Cochrane Database of Systematic Reviews 2015; Issue 6. Article number CD009229. PMID 26118544. *Co-first author
- Agarwalla PK, Stapleton CJ, Phillips MT, Walcott BP, Venteicher AS, Ogilvy CS. Surgical outcomes following encephaloduroarteriosynangiosis in North American adults with moyamoya. Journal of Neurosurgery 2014 Oct 3;1-7. PMID 25280094
- Grannan BL, Yanamadala V, Venteicher AS, Walcott BP, Barr JC. Use of external ventriculostomy and intrathecal anti-fungal treatment in cerebral mucormycotic abscess. Journal of Clinical Neuroscience 2014 Oct; 21(10):1819- 1821. PMID 24852901
- Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. Glioblastoma mimicking an arteriovenous malformation. Frontiers in Neurology 2013 Sept 30;4:144. PMCID 3786388
- Codd PJ, Venteicher AS, Agarwalla PK, Kahle KT, Jho DH. Endoscopic burr hole evacuation of an acute subdural hematoma. Journal of Clinical Neuroscience 2013 Dec; 20(12): 1751-3. PMID 23962631
- Venteicher AS, Walcott BP, Sheth SA, Snuderl M, Patel AP, Curry WT, Nahed BV. Clinical features of brain metastasis from salivary gland tumors. Journal of Clinical Neuroscience 2013 Nov; 20(11):1533-7. PMCID 3749258
- Hayden Gephart MG, Hansasuta A, Balise RR, Choi C, Sakamoto GT, Venteicher AS, Soltys SG, Gibbs IC, Harsh GR, Adler JR, Chang SD. Cochlea radiation dose correlates with hearing loss after stereotactic radiosurgery of vestibular schwannoma. World Neurosurgery 2013 Sept-Oct; 80(3-4):359-63. PMID 22484770
Scientific Publications
- Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, Artandi SE. An activity switch in human telomerase based on RNA conformation and shaped by TCAB1. Cell 2018 May 18. PMID 29804836.
- Venteicher AS*, Tirosh I*, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichandran H, Mylvaganam R, Mount C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje M, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A**, Suva ML**. Decoupling genetics, lineages, and tumor microenvironment in gliomas by single-cell RNA-seq. Science 2017 Mar 31; 355(6332). PMID 28360267.
- Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Herbert CH, Carey CD, Rodig SJ, Shareef SJ, Najm FJ, van Galen P, Wakimoto H, Cahill DP, Rich JN, Aster JC, Suva ML, Patel AP, Bernstein BE. Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance. Cell Stem Cell 2017 Feb 2; 20(2): 233-246. PMID 27989769
- Tirosh I*, Venteicher AS*, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt- Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A**, Suva ML**. Single-cell RNA seq supports a developmental hierarchy in human oligodendroglioma. Nature 2016 Nov 2; 539(7628): 309-313. PMID 27806376.
- Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, Suva ML, Bernstein BE. Insulator dysfunction and oncogene activation in IDH1 mutant gliomas. Nature 2016 Jan 7; 529(7584): 110-4. PMID 26700815
- Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG 2nd, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson M. Rapid intraoperative molecular characterization of glioma. JAMA Oncology 2015 Aug 1; 1(6): 662-667. PMID 2618761
- Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell 2014 Dec 4; 159(6): 1389-403. PMID 25467444
- Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 2012 Aug 3; 150(3): 481-94. PMCID 3516183
- Park JI, Venteicher AS*, Hong JY*, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea P, Artandi SE. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 2009 July 2: 460(7251): 66-72. PMID 19571879.
- Venteicher AS, Artandi SE. TCAB1: Driving telomerase to Cajal bodies. Cell Cycle 2009 May 1; 8(9): 1329-31. PMID 19342896
- Venteicher AS, Abreu EB, Meng Z, McCann KE, Terns RD, Veenstra TD, Terns MP, Artandi SE. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science 2009 Jan 30; 323(5914): 644-8. PMCID 2728071
- Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE. Identification of ATPases pontin and reptin as telomerase complex components essential for holoenzyme assembly. Cell 2008 Mar 21; 132(6): 945-57. PMCID 2291539
- Choi J, Southworth LK, Sarin KY, Venteicher AS, Ma W, Chang W, Cheung P, Jun S, Artandi MK, Shah N, Kim SK, Artandi SE. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genetics 2008 Jan; 4(1): 124-138. PMCID 2211538
- Middleman EJ, Choi J, Venteicher AS, Cheung P, Artandi SE. Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Molecular and Cellular Biology 2006 Mar; 26(6): 2146-59. PMCID 1430280
- Venteicher A, Armstead WM. Vasopressin contributes to dynorphin modulation of hypoxic cerebrovasodilation. American Journal of Physiology 1998 Dec; 275(6 Pt 2): H2072-9. PMID 9843806.
Book Chapters
- Venteicher AS, Rosand J, Curry WT. Gliomas. Neurocritical care for the Neurosurgical Patient. Publisher: Elsevier, first edition. Editors M Kumar, J Levine, J Schuster, W Kofke. 2017 Mar. ISBN 978-0-32-3321068
- Scripko PD, Venteicher AS, Plotkin SR. Nerve sheath tumors. Encyclopedia of the Neurological Sciences, Edition 2E. Editors Michael Aminoff and Robert Daroff. 2014. ISBN 978-0-12-38515801.