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Cytogenomics

The Cytogenomics branch of the Cancer Genomics Shared Resource (CGSR) provides comprehensive chromosomal and genomic structural analysis services. Our capabilities include high-quality G-band karyotyping for human, animal models, ES/iPS cells, blood, bone marrow, and fresh tissues. Multi-color Spectral Karyotyping (SKY) analysis is utilized to resolve structural abnormalities and assess tumor heterogeneity at single-cell resolution. 

The core also supports a full suite of fluorescence-in-situ-hybridization (FISH) assays, with custom site-specific probes generated from BAC/PAC clones or investigator-provided DNA, as well as commercially available probe options. Additionally, the core offers optical genome mapping using the Bionano Saphyr platform, enabling high-resolution detection of structural variants, genome-wide assessment of chromosomal integrity, and comprehensive analysis of complex genomic rearrangements.

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Services

  • Standard G-band Karyotype analysis (20 cells)
  • Quick QC Karyotype analysis (7 cells)
  • Bionano Optical Genome Mapping
  • Fluorescent in-situ Hybridization (FISH): commercial, homebrew BAC, homebrew DNA
  • Spectral Karyotyping (SKY) Multi-color FISH
  • Hourly rate for projects falling outside the traditional service framework

Instrumentation

  • Applied Spectral Imaging HyperSpectral Platform for SKY, FISH and G-band karyotyping
  • Quantstudio 3 PCR System
  • Bionano Saphyr (Optical Genome Mapping)
  • Qubit Fluorimeter 
  • HemoCue